Vaccines

Some MMR formulations include hydrolyzed gelatin as a stabilizer; the species (porcine vs bovine) is listed in the FDA package insert.

Pfizer-BioNTech and Moderna confirm no porcine or other animal products in the final formulation.

Most seasonal flu vaccines are egg-grown; Flucelvax is grown in mammalian (MDCK) cells.

Trace porcine circovirus DNA was detected in Rotarix in 2010. The FDA reviewed and concluded there is no safety concern; the vaccine continues to be used worldwide.

Gardasil 9 is produced in yeast; the package insert lists no porcine, bovine, or other animal-derived components in the final product.

Hepatitis B surface antigen (HBsAg) is produced in yeast; package inserts list no porcine or bovine ingredients in the final formulation.

Both Havrix and Vaqta are produced in MRC-5, a human diploid cell line established in 1966.

Varivax lists hydrolyzed gelatin as a stabilizer; species (typically porcine) is in the FDA insert.

Current DTaP and Tdap package inserts (Infanrix, Boostrix, Adacel, Daptacel) do not list gelatin.

IPOL uses calf bovine serum during Vero cell growth; bovine material is sourced from BSE-free regions per FDA.

Prevnar 20 and Vaxneuvance package inserts do not list porcine, bovine, or gelatin ingredients.

Saudi Arabia requires a valid quadrivalent meningococcal certificate for pilgrims aged 1 year and older.

Hib vaccines are bacterial conjugates with no animal cell line involvement in the final product.

Shingrix is a recombinant subunit vaccine and contains no live virus, unlike the older Zostavax.

Nirsevimab is a long-acting monoclonal antibody that provides direct protection rather than triggering an immune response.

Abrysvo is recommended during 32–36 weeks gestation in RSV season to pass antibodies to the infant.

YF-Vax (Sanofi Pasteur) lists hydrolyzed porcine gelatin in its FDA package insert; Stamaril (used outside the US) historically uses similar stabilizer.

Typhim Vi is an injectable polysaccharide vaccine; Vivotif is an oral live-attenuated capsule (4 doses).

RabAvert's stabilizer is polygeline, a modified bovine gelatin; Imovax uses human albumin instead.

BCG is derived from a weakened strain of Mycobacterium bovis attenuated over many years in culture; it is not a chemical or animal-tissue product.